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Endocrine Abstracts

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ea0065p170 | Metabolism and Obesity | SFEBES2019

Chronic disruption of endothelial Insulin/IGF1 signaling pathway enhances whole body insulin sensitivity

Viswambharan Hema , Yuldasheva Nadira , Imrie Helen , Cubbon Richard , Bridge Katherine , Haywood Natalie , Skromna Anna , Porter Karen , Hemmings Karen , Clark Emily , Gatenby Victoria , Abudushalamu Yilizila , Cordell Paul , Simmons Katie , Makava Natallia , Walker Andrew , Futers Simon , Shah Ajay , Beech David , Wheatcroft Stephen , Kearney Mark , Sukumar Piruthivi

Type 2 diabetes is preceded by insulin resistance, followed by increased endothelial cell production of superoxide and reduction in bioavailability of the vasoprotective signalling molecule, nitric oxide (NO). We demonstrated in preclinical models that type 2 diabetes also causes resistance to insulin-like growth factor-1 (IGF-1) mediated glucose lowering and endothelial NO release. This study aimed to examine the effect of the endothelial cell-specific combination of insulin ...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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